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KMID : 0988920100080010018
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Intestinal Research
2010 Volume.8 No. 1 p.18 ~ p.23
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The Usefulness of F18-FDG PET/CT in Detection of Colonic Neoplasm
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Kang Min-Kyung
Hong Sung-Hwa
Lee Ji-Eun
Kim Jong-Woo
Kwon Chang-Il
Ko Kwang-Hyun
Hwang Seong-Gyu
Park Pil-Won
Rim Kyu-Seong
Jeon Tae-Joo
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Abstract
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Background/Aims: The diagnostic value of 2-18F-fluoro-2-deoxy-D-glucose positron emi-ssion to-mo--graphy (FDG PET)/CT in the detection of colon carcinoma and adenoma was evaluated retrospectively.
Methods: Between May 2007 and June 2008, 102 patients (42 males and 60 females: age range, 28-89 years) underwent both FDG PET/CT and colonoscopy in < a 3 month interval. FDG uptake on PET/CT was divided into physiologic and pathologic uptake by a nuclear medicine specialist. Pathologic confirmation was obtained in all patients.
Results: Forty-three patients had no abnormal findings on both FDG PET/CT and colonoscopy. One hundred five and 59 colonic lesions were detected on FDG PET/CT and colonoscopy, respectively. Eleven of 24 lesions with pathologic FDG uptake were histologically-confirmed to be malignancies. Among 18 lesions with physiologic FDG uptake, 1 carcinoma and 1 adenoma were revealed. One carcinoma, 25 adenomas, and 11 hyperplastic polyps did not reveal FDG uptake. Interpretation of pathologic FDG uptake in the colon had a sensitivity of 84.6% and 28.2%, a specificity of 90.4% and 88.1%, a positive predictive value of 45.8% and 45.8%, and a negative predictive value of 98.4% and 77.8% for carcinomas and adenomas, respectively.
Conclusions: FDG PET/CT is a very useful diagnostic method for the detection of colon cancer, but the sensitivity is low for adenomas, which may need further evaluation, such as a screening endoscopy.
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KEYWORD
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PET/CT, Colonoscopy, Colonic Neoplasms
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